Functional expression of aquaporins in embryonic, postnatal, and adult mouse lenses

K Varadaraj, SS Kumari… - … dynamics: an official …, 2007 - Wiley Online Library
… The work presented here demonstrates the characteristic patterns of AQP0 and AQP1
expression in embryonic, postnatal, and adult mouse lenses. It also offers insights into the function/…

Spatial distributions of AQP5 and AQP0 in embryonic and postnatal mouse lens development

RS Petrova, KL Schey, PJ Donaldson… - Experimental eye …, 2015 - Elsevier
… The expression of the water channel protein aquaporin (AQP)… of AQP5 during embryonic
and postnatal lens development … AQPs are established in the adult lens. The high resolution …

Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice

A Shiels, S Bassnett, K Varadaraj… - Physiological …, 2001 - journals.physiology.org
… on lens function, we have generated AQP0 deletion mice using a gene trapping strategy (35)
that allows random targeting of genes in embryonicmouse lens at 3 wk of age (postpartum

[HTML][HTML] Aquaporins in development–a review

H Liu, EM Wintour - Reproductive Biology and …, 2005 - rbej.biomedcentral.com
aquaporin genes, this is complicated by the facts that either much of normal organ development
occurs postnatally in … The role of aquaporins in fluid balance during fetal development is …

The role of aquaporins in ocular lens homeostasis

KL Schey, RS Petrova, RB Gletten… - International journal of …, 2017 - mdpi.com
expression in the lens embryonic epithelium at embryoniclens embryonic development to
facilitate formation of the ordered cellular architecture of the adult lens, while during postnatal

Aquaporins in the eye: expression, function, and roles in ocular disease

KL Schey, Z Wang, JL Wenke, Y Qi - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
… , mutations in other lens aquaporins have not been associated with lens phenotypes in …
in the NBL suggests the potential involvement of APQ3 in the postnatal retina development. …

[HTML][HTML] Unique and analogous functions of aquaporin 0 for fiber cell architecture and ocular lens transparency

SS Kumari, S Eswaramoorthy, RT Mathias… - … et Biophysica Acta (BBA …, 2011 - Elsevier
… Overall, there were no significant structural differences between WT and TgAQP1 +/+ mice
lenses at low or high magnification in embryonic (E11.25–E19.5), as well as postnatal lenses (…

Transgenic expression of AQP1 in the fiber cells of AQP0 knockout mouse: effects on lens transparency

K Varadaraj, SS Kumari, RT Mathias - Experimental eye research, 2010 - Elsevier
… life with the oldest embryonic primary fiber cells occupying … model expressing a non-native
aquaporin (AQP1) in the lens … prenatal, postnatal and adult lenses of the transgenic mouse, …

[HTML][HTML] Aquaporins have regional functions in development of refractive index in the zebrafish eye lens

K Wang, I Vorontsova, M Hoshino… - … & Visual Science, 2021 - jov.arvojournals.org
… Zebrafish Aqp0a, but not Aqp0b, requires water transport function to maintain embryonic
lens transparency, 24 which in turn impacts the concentration gradients of crystallin proteins. …

Verification and spatial localization of aquaporin-5 in the ocular lens

AC Grey, KL Walker, RS Petrova, J Han… - Experimental eye …, 2013 - Elsevier
expressed in the lenses of a variety of species and show that AQP5 expression changes as
a function … protein expression occurs in mouse, rat, bovine and human lenses, indicating that …